Angiogénesis Tumoral: estrategias diagnósticas y terapéuticas

Ximena Camacho; Pablo Cabral

doi:10.35954/SM2012.31.1.5

Autores/as

Ximena Camacho Departamento de Radiofarmacia, Centro de Investigaciones Nucleares,Facultad de Ciencias, Universidad de la República (UdelaR). https://orcid.org/0000-0002-0755-3834
Pablo Cabral Departamento de Radiofarmacia, Centro de lnvestigaciones Nucleares, Facultad de Ciencias, Universidad de la Republica, Montevideo, Uruguay https://orcid.org/0000-0001-7344-2027

DOI:

https://doi.org/10.35954/SM2012.31.1.5

Palabras clave:

Angiogénesis Tumoral; Inhibidores de la Angiogénesis; VEGF.

Resumen

La angiogénesis es fundamental para el desarrollo tumoral, y el período durante el cual se produce la transición de la fase tumoral avascular a la fase vascular, se encuentra regulado por la expresión de factores pro-angiogénicos como el factor de crecimiento endotelial vascular (VEGF). Esta sustancia es una glicoproteína que es producida ya sea por las células normales como las neoplásicas y juega un rol muy importante tanto en situaciones fisiológicas como patológicas. La unión del VEGF a sus receptores conduce al reclutamiento de señales moleculares intracelulares responsables de la supervivencia, permeabilidad vascular, migración y proliferación celular. Muchos estudios han descripto la relación que existe entre la expresión del VEGF y el pronóstico de los pacientes en patologías oncológicas. Tanto el VEGF como sus receptores han sido blancos para el desarrollo de numerosos agentes terapéuticos y de diagnóstico. En el presente trabajo se hace una descripción de algunos de estos agentes, así como sus estrategias y/o mecanismos para visualizar o inhibir la angiogénesis tumoral.

Recibido para revisión: junio 2012.
Aceptado para publicación: agosto 2012.

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