Biomarkers of physical activity and sport

Authors

DOI:

https://doi.org/10.35954/SM2021.40.2.5.e402

Keywords:

Lactic Acid; Biomarkers; Creatin Kinase; Lactate Dehydrogenase; Troponin.

Abstract

Biomarkers measure the body's adaptation to physical training through variations in blood concentrations. These modifications can be benign and reversible or negative, hence the importance of studying their implications.

Lactate is an indicator of exercise intensity through the variation of its blood concentration, which increases in more intense exercise. In low intensity exercise, lactate and glucose concentrations gradually decrease, because they use fatty acids as the predominant energy source before glycolysis. High lactate concentrations favor the colonization of Veillonella at intestinal level, improving running time by the metabolic conversion of lactate to propionate and its disposition as an energy source directly, without the effect of first hepatic passage.

Troponin is specific for diagnosing cardiac injury. It increases asymptomatically after intense training, proportional to the time and intensity of training. The post-exercise increase is greater in less trained athletes, in athletes adapted to high-intensity intermittent exercise, it rises significantly after intermittent exercise and not after continued exercise, evidencing the a Biomarkers measure the body's adaptation to physical training through variations in blood concentrations. These modifications can be benign and reversible or negative, hence the importance of studying their implications.

Lactate is an indicator of exercise intensity through the variation of its blood concentration, which increases in more intense exercise. In low intensity exercise, lactate and glucose concentrations gradually decrease, because they use fatty acids as the predominant energy source before glycolysis. High lactate concentrations favor the colonization of Veillonella at intestinal level, improving running time by the metabolic conversion of lactate to propionate and its disposition as an energy source directly, without the effect of first hepatic passage.

Troponin is specific for diagnosing cardiac injury. It increases asymptomatically after intense training, proportional to the time and intensity of training. The post-exercise increase is greater in less trained athletes, in athletes adapted to high-intensity intermittent exercise, it rises significantly after intermittent exercise and not after continued exercise, evidencing the adaptation of the organism to a specific type of exercise.

There are typical post-exercise biochemical alterations, characterized by an increase in total creatine kinase and its fractions. It occurs after strenuous exercise that can cause muscle overload, muscle fiber rupture and inflammation, releasing these biochemical markers into the bloodstream.

Different high-intensity and high-performance sports disciplines produce increased lactate dehydrogenase indicating risk of injury due to deterioration of muscle fibers.daptation of the organism to a specific type of exercise.

There are typical post-exercise biochemical alterations, characterized by an increase in total creatine kinase and its fractions. It occurs after strenuous exercise that can cause muscle overload, muscle fiber rupture and inflammation, releasing these biochemical markers into the bloodstream.

Different high-intensity and high-performance sports disciplines produce increased lactate dehydrogenase indicating risk of injury due to deterioration of muscle fibers.

Received for review: August 2021
Accepted for publication: October 2021
Correspondence: 8 de octubre 3020. C.P.11600. Montevideo, Uruguay. Tel: (+598) 24876666 ext. 1663.

Contact e-mail: vortizalfonzo@gmail.com

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References

(1) Roca E. Disponible en: https://www.emmaroca.com/cientifica-es. [Consulta 12/9/2021]. Sitio web. 1 página en pantalla.

(2) Palacios G, Pedrero-Chamizo R, Palacios N, Maroto-Sánchez B, Aznar S, González-Gross M. Biomarcadores de la actividad física y del deporte. Nutrición Hospitalaria 2015; 31(Extra 3):237-244.

(3) Lee E, Fragala M, Kavouras S, M Queen R, Pryor J, Casa D. Biomarkers in sports and exercise: tracking health, performance, and recovery in athletes. J Strength Cond Res 2017; 31(10):2920-2937. doi: 10.1519/JSC.0000000000002122.

(4) Sierra A, Ghorayeb N, Dioguardi G, Sierra C, Peduti M. Alteracao de biomarcadores de lesao miocárdica em atletas após a maratona internacional de sao Paulo. Rev Bras Med Esporte 2015; 21(3). https://doi.org/10.1590/1517-86922015210302223

(5) Finisterer J. Biomarkers of peripheral muscle fatigue during exercise. BMC Musculoskeletel Disorders 2012; 13:218. doi: 10.1186/1471-2474-13-218.

(6) Brooks G. The Science and Translation of Lactate Shuttle Theory. Cell Metabolism 2018; 27(4):757-785. DOI: https://doi.org/10.1016/j.cmet.2018.03.008.

(7) Yang W, Park H, Grau M, Heine O. Decreased Blood Glucose and Lactate: Is a Useful Indicator of Recovery Ability in Athletes? Int J Environ Res Public Health 2020; 17(15):5470. doi: 10.3390/ijerph17155470

(8) Scheiman J, Luber J, Chavkin T, Mc Donald T, Tung A, Pham L, et al. Meta’omic analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism. Nat Med 2019 Jul; 25(7):1104-1109. doi: 10.1038/s41591-019-0485-4. Epub 2019 Jun 24.

(9) Palacios G, Pedrero-Chamizo R, Palacios N, Maroto-Sánchez B, Aznar S, González-Gross M; EXERNET Study Group. Biomarkers of physical activity and exercise. Nutr Hosp. 2015 Feb 26; 31 Suppl 3:237-44. doi: 10.3305/nh.2015.31.sup3.8771.

(10) Wedin J, Nyberg N, Henriksson A. Impact of training specificity on exercise-induced cardiac troponin; elevation in professional athletes: A pilot study. World J Cardiol 2020; 12(1):35-43. doi: 10.4330/wjc.v12.i1.35.

(11) Importancia del principio de la especificidad en el ciclista. Disponible en: https://www.efdeportes.com/efd112/principio-de-la-especificidad-en-el-ciclista.htm. [Consulta 12/9/2021] Sitio web. 1 página en pantalla.

(12) Saez J. Blog. Disponible en: https://www.jlmartinsaez.com/articulos/yo-yo-intermittent-recovery-tes. [Consulta 12/9/21] Sitio web. 1 página en pantalla.

(13) Zambrano-Montesdeoca A, Rendón-Párraga J, Trujillo-Chávez M, Valero-Cedeño N. Concentración sérica de creatina-quinasa y funcionalismo renal en adultos de centros de entrenamiento físico de Calceta. Dom. Cien 2019; 5(1)818-843. http://dx.doi.org/10.23857/dc.v5i1.1085.

(14) De Olivera Siqueira L, Muccini T, Dall Agnol I, Filla L, Tibbola P, Luvison A, et al. Análise de parâmetros bioquímicos séricos e urinários em atletas de meia maratona. Arq Bras Endocrinol Metab. 2009; 53(7). https://doi.org/10.1590/S0004-27302009000700008.

(15) Kanda K, Sugama K, Sakuma K, Kawakami Y, Suzuki K. Evaluation of serum leaking enzymes and investigation into new biomarkers for exercise induced muscle damage. Excentric excercise and muscle damage markers. Exerc Immunol Rev 2014; 20:39-54. PMID: 24974720.

(16) Montero J, Lovesio C, Godoy M, Ruiz G. Rabdomiolisis por spinning en nueve pacientes. MEDICINA (Buenos Aires) 2009; 69:153-156.

(17) Koch A, Pereira R, Machado M. The creatine Kinase response to resistence exercise. Musculoskelet Neuronal Interact 2014; 14(1):68-77.

(18) Gallo-Salazar C, González-Millán C, Garrigós J, Salinero Martín JJ, Abián-Vicén J, Ruiz-Vicente D, et al. Influencia de un medio ironman en parámetros sanguíneos. Arch Med Deporte 2015; 32(1):10-15.

(19) Radzimiński Ł, Jastrzębski Z, López-Sánchez GF, Szwarc A, Duda H, Stuła A, et al. Relationships between training loads and selected blood parameters in professional soccer players during a 12-day sport camp. Relationships between Training Loads and Selected Blood Parameters in Professional Soccer Players during a 12-Day Sports Camp. Int J Environ Res Public Health. 2020 Nov 19; 17(22):8580. doi: 10.3390/ijerph17228580.

(20) Ferreira PF. Influencia de un método de treinamento físico militar sobre marcadores indiretos de dano muscular. Rio de Janeiro; s.n; 2020. 67 p. Tesis en Portugués. Disponible en: https://pesquisa.bvsalud.org/portal/resource/es/biblio-1177775 [Consulta 17/9/2021].

Published

2021-12-31

How to Cite

1.
Ortiz V, Nieves V, Laulhé Pontolillo SB, Rivero M. Biomarkers of physical activity and sport. Salud Mil [Internet]. 2021 Dec. 31 [cited 2026 Apr. 28];40(2):e402. Available from: https://www.revistasaludmilitar.uy/ojs/index.php/Rsm/article/view/220

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