Linfoma não-Hodgkin: uso de emissores gama para diagnóstico
DOI:
https://doi.org/10.35954/SM2015.34.1.7Palavras-chave:
Câncer; Emissores gama; Linfoma não-Hodgkin; Emissão de Positron; PositronsResumo
24,8% das mortes no Uruguai são devidas ao câncer. O linfoma não-Hodgkin (NHL) é a neoplasia hematológica mais freqüente e a quinta causa mais comum de mortes por câncer no mundo, mais de 90% das quais têm origem em linfócitos B e expressam o antígeno CD20. O anticorpo monoclonal Rituximab® reconhece este antígeno de superfície com alta afinidade e é usado no tratamento de NHL CD20-positivo. Atualmente, além do Rituximab®, a FDA aprovou o uso do anticorpo anti-CD20 associado aos emissores beta (1311, 90Y), o que aumenta seu efeito e aumenta sua eficácia terapêutica.
Este estudo visa demonstrar que o desenvolvimento de novos agentes de imagem usando anticorpos monoclonais direcionados contra alvos específicos da superfície celular e acoplados a emissores gama ou emissores positron convencionais poderia melhorar a sensibilidade e a especificidade da imagem para a estatificação desta patologia.
Recebido para revisão: março de 2015
Aceito para publicação: Junho de 2015
Correspondência: Laboratorio de Radiofarmacia, Centro de lnvestigaciones Nucleares, Facultad de Ciencias, Universidad de la Republica. Mataojo 2055, C.P. 11400, Montevidéu, Uruguai. Tel: (+598)25250901/108; fax: (+598)25250895.
E-mail de contato: pcabral@cin.edu.uy
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